Abstract
We report here that microtubules in vitro coexist in growing and shrinking populations which interconvert rather infrequently. This dynamic instability is a general property of microtubules and may be fundamental in explaining cellular microtubule organization.
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References
Roberts, K. & Hyams, J. Microtubules (Academic, London, 1977).
McIntosh, J. R. Mod. Cell Biol. 2, 115–142 (1983).
Mitchison, T. J. & Kirschner, M. Nature 312, 232–237 (1984).
Bergen, L. G. & Borisy, G. G. J. Cell Biol. 84, 141–150 (1980).
Allen, C. & Borisy, G. G. J. molec. Biol. 90, 381–402 (1974).
Summers, K. & Kirschner, M. W. J. Cell Biol. 83, 205–217 (1979).
Hill, T. L. & Kirschner, M. W. Int. Rev. Cytol. 84, 185–234.
Carlier, M.-F., Hill, T. L. & Chen, Y.-D. Proc. natn. Acad. Sci. U.S.A. 81, 771–775 (1984).
Oosawa, F. & Asakura, S. Thermodynamics of the Polymerization of Protein (Academic, New York, 1975).
Carlier, M.-F., Pantaloni, D. & Korn, E. D. J. biol. Chem. (in the press).
Kristofferson, D. & Purich, D. L. Archs Biochem. Biophys. 211, 222–226 (1981).
Hill, T. L. & Carlier, M.-F. Proc. natn. Acad. Sci. U.S.A. 80, 7234–7238 (1983).
Carlier, M.-F. & Pantaloni, D. Biochemistry 20, 1918–1924 (1981).
Hill, T. L. & Chen, Y.-D. Proc. natn. Acad. Sci. U.S.A. (in the press).
Hill, T. Proc. natn. Acad. Sci. U.S.A. (in the press).
Margolis, R. L. & Wilson, L. Cell 13, 1–8 (1978).
Farrell, K. W. & Jordan, M. A. J. biol. Chem. 257, 3131–3138 (1982).
Cote, R. H. & Borisy, G. G. J. molec. Biol. 150, 577–602 (1981).
Jameson, L. & Caplow, M. J. biol. Chem. 255, 2284–2292 (1980).
Karr, T. L., Kristofferson, D. & Purich, D. L. J. biol. Chem. 255, 8560–8655 (1980).
Pickett-Heaps, J., Tippit, D. H. & Porter, K. R. Cell 29, 729–744 (1982).
Mitchison, T.J. & Kirschner, M.W. in Molecular Biology of the Cytoskeleton (eds Cleveland, D. W., Murphy, D. & Borisy, G. G.) (Cold Spring Harbor Laboratory, New York, in the press).
McIntosh, J. & Salmon, E. D. J. Cell Biol. (in the press).
Thompson, G. A., Baugh, C. C. & Walker, L. F. J. Cell Biol. 61, 253–257 (1974).
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Mitchison, T., Kirschner, M. Dynamic instability of microtubule growth. Nature 312, 237–242 (1984). https://doi.org/10.1038/312237a0
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DOI: https://doi.org/10.1038/312237a0
